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Immense contains Sildenafil, a selective and reversible phosphodiesterase type 5 (PDE5) inhibitor. During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum, which increases cyclic guanosine monophosphate (cGMP) levels. Immense inhibits PDE5, preventing cGMP breakdown, causing smooth muscle relaxation, increased blood inflow, and penile erection. Sildenafil has no effect without sexual stimulation.
Pharmacokinetics:
- Absorption: Rapid; peak plasma levels within 30–120 minutes (median 60 min). High-fat meals may delay absorption.
- Metabolism: Primarily hepatic via CYP3A4, minor via CYP2C9. Active metabolite has similar properties.
- Excretion: Mostly in feces (~80%), some in urine (~13%).
- Half-life: ~4 hours.
- Special Populations: Elderly (>65) show reduced clearance, increasing plasma exposure.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Immense is indicated for the treatment of:
Erectile dysfunction (ED) in men, characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Sexual stimulation is required for Immense to be effective.
Pulmonary arterial hypertension (PAH).
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✔️ Side Effects of Immense 50
Common: headache, flushing, dyspepsia, nasal congestion, dizziness, visual disturbances.
Serious (rare):
Cardiovascular: myocardial infarction, arrhythmias, stroke, hypotension.
Prolonged erections (>4 hours), priapism.
Visual/hearing disturbances, sudden vision loss.
Severe hypotension with concomitant alpha-blockers or antihypertensives.
Caution in patients with preexisting cardiovascular disease.
✔️ Dosage & Administration | Immense 50
Erectile Dysfunction:
- Typical starting dose: 50 mg, 0.5–4 hours before sexual activity.
- Dose adjustment: 25–100 mg based on efficacy and tolerability.
- Maximum: Once daily.
Special considerations:
- Reduced starting dose (25 mg) in patients >65, with hepatic/renal impairment, or on strong CYP3A4 inhibitors.
- Contraindicated with nitrates due to the risk of severe hypotension.
- Caution when combined with alpha-blockers; ensure hemodynamic stability and start at the lowest dose.
Pulmonary Arterial Hypertension:
- 20 mg three times daily, 4–6 hours apart, with or without food.
Use only as directed by a registered physician.
✔️ Interaction
CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir) increase Immense plasma levels significantly.
CYP3A4 inducers (rifampin, bosentan) may reduce plasma levels.
No significant effect with CYP2C9, CYP2D6 inhibitors, antacids, ACE inhibitors, calcium channel blockers, or thiazide diuretics.
✔️ Contraindications
Hypersensitivity to Sildenafil.
Concomitant use with organic nitrates (regular or intermittent).
✔️ Pregnancy & Lactation
Category B; not indicated for women.
Animal studies show no teratogenicity.
✔️ Precautions & Warnings
Evaluate underlying causes of ED before prescribing.
- Use caution in:
- Anatomical penile deformities (Peyronie’s disease, cavernosal fibrosis)
- Conditions predisposing to priapism (sickle cell anemia, leukemia, multiple myeloma)
- Patients with cardiovascular instability, recent MI/stroke, uncontrolled hypertension or hypotension
- Seek immediate medical attention for erections >4 hours.
- Dose adjustment required with ritonavir due to high systemic exposure.
✔️ Storage:
Store in a dry place, protected from light and heat.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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